Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate.

BACKGROUND Severe pulmonary hypertension may following ibuprofen administration for ductal closure. CASE CHARACTERISTICS An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration. OUTCOME Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications related to bronchopulmonary dysplasia. MESSAGE Sildenafil may have a role in treatment of severe pulmonary hypertension after ibuprofen treatment for ductal closure.